B1. Academic Medical Center Amsterdam, Universiteit van Amsterdam,The Netherlands (AMC)
Principal Investigator for hyperthermia research. His research interests focus on the development of hyperthermia techniques to achieve well controlled tumour heating without overheating normal tissue, and using these in clinical studies to establish the clinical benefit of hyperthermia for different tumour sites. Also working in preclinical research into the synergistic actions of hyperthermia and radiotherapy and chemotherapy to arrive at optimal treatment schedules. Long_Bio
hyperthermia, phased array systems, radiosensitization
Senior researcher at the Amsterdam UMC, dept. Radiation oncology. Her research line focuses on several aspects of hyperthermia treatment planning; e.g. clinical planning using on-line adaptive strategies, advanced thermal modelling, MR imaging to reconstruct patient-specific tissue properties, and biological modelling to quantify hyperthermic sensitization. Long_Bio
Hyperthermia treatment planning, biological modelling, treatment optimization.
After obtaining his PhD Cum Laude in 2009, at the AMC, focusing on the interactions between DNA repair and hyperthermia in the context of cancer, he spent 2 years in the lab of Dr. Maria Jasin at the Memorial Sloan Kettering Cancer Center in NY, where he studied the repair of (CRISPR-induced) DNA breaks in vitro and in vivo. Then he established his research group at the Amsterdam UMC, where he currently focuses on (1) the preclinical and translational research related to hyperthermia-based therapies and (2) advanced visualization and analysis of early cellular responses to DNA double-strand breaks induced by x-rays and accelerated particles.
Microscopy, DNA repair, Hyperthermia
Studied medicine in Nijmegen, NL where he received his MD (1985), PhD (1991), and training in radiation oncology (1995). He was a junior researcher at Sunnybrook Health Siences Center, University of Toronto (1993), and did a fellowship in neuro-oncology at UCSF San Francisco (1994-1995). Since 1995, he is staff member in radiation oncology at the Amsterdam UMC, location AMC, became chair of the radiation residents training program, and full professor of translational radiotherapy (2015). His focus is on translational research in pelvic tumours, particularly in gynaecological cancer. Together with a team of physicists, radiobiologists and clinicians, he works on methods to improve radiation precision, tumour control i.e. by combined modality treatment of radiation with chemotherapy, hyperthermia and targeted drugs, and to reduce radiation toxicity. Long_Bio
Arlene Leonie Oei
Arlene Leonie Oei is a group leader of the radiobiology and hyperthermia research at the department of Radiation Oncology, at the Amsterdam UMC. Her research focusses on improving current anti-cancer treatment strategies, by investigating the mechanisms of action of hyperthermia, radiotherapy, PARP1-inhibitors and immune modulators in 2D, 3D in vitro cultures and in in vivo models. Long_Bio
Hyperthermia, Radiotherapy, Immunotherapy
Arjan Bel is head of the radiotherapy physics group at the Amsterdam UMC. His full career he has been working in radiotherapy in academic hospitals as well as a company. His main interests are image guided adaptive radiotherapy and its combination with hyperthermia. He is (co-) author of 150 peer-reviewed papers (check here).
Keywords image guided adaptive radiotherapy, hyperthermia, brachytherapy
Since 1998, Ben Slotman has served as Professor and Head of the Department of Radiation Oncology at Vrije Universiteit medical center (VUmc) in Amsterdam, The Netherlands. Since 2019, he is also the head of the department of Radiation Oncology at the Academic Medical Center (AMC) in Amsterdam. His expertise lies mainly in the field of radiotherapy for lung and brain malignancies and the early clinical implementation of new technologies. His research activities are further concentrated on intra- and extracranial stereotactic radiotherapy and the introduction of various new technologies in radiotherapy, most recently stereotactic MRI-guided adaptive radiotherapy. Professor Slotman is the (co-)author of over 400 international peer reviewed publications. Long_Bio
(adaptive) Radiotherapy, new technologies