ESR 10: Requirements clinical RT+HT treatment data reporting

PhD research

Host: Professor Gerard van Rhoon

Recruiting organization: Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands

Duration: 36 months

Background

Clinical studies by individual institutes indicate that treatment outcome after radiotherapy (RT) plus hyperthermia (HT) shows an independent correlation with the RT and HT dose. Obtaining similar evidence from multi-institutional clinical trials requires uniform guidelines on treatment data reporting. Development and validation of RT and HT dose parameter data set is a challenging, but rewarding, goal considering the large variation in procedures of the involved institutes.

Approach 

The PhD candidate needs to reach consensus on guidelines for combined RT+HT treatment data reporting suitable for multi-center clinical trials. This will require a dual approach of setting up a template for separate data collection of the RT and HT dose parameters as well as treatment outcome parameters. The basic dose parameters will be used to calculate the combined effective RT+HT dose, i.e. the biological equivalent RT-dose, that was delivered during the clinical treatment.

The candidate will start with analyzing all reported dose effect relationships from clinical trials performed using combined treatments of RT+HT in a systematic review of the literature. From the review, relevant clinical parameters will be identified and a comprehensive, complete data reporting template of combined RT+HT will be defined. Validation of the selected dose parameters to predict treatment outcome, using independent clinical data of the involved institutes is a key aspect of the study. Challenges to be addressed concern: different institutes, HT devices, patient documentation platforms, combination of high temporal and 3D spatial resolution of the RT-dose with low, both in time and space, resolution of thermal dose when measured with temperature probes only.

Our research team

Gerard van Rhoon (Erasmus MC – Professor)

Martine Franckena (Erasmus MC – Radiation Oncologist)

Sergio Curto (Erasmus MC – Hyperthermia Physicist)

Maarten Paulides (Erasmus MC and Eindhoven University – Associate Professor)

Your experience

  • Candidates should have a MD-degree with interest and skills in data analysis – collecting or a MSc in Technical Medicine or similar
  • Advanced medical knowledge and experience with MRI imaging
  • Experience in programming and statistical data analyzing methods
  • Strong analytical and mathematical skills
  • Excellent higher education track record and strong scientific curiosity
  • Fluent spoken and written English skills

In addition, the following experience would be helpful, but not essential:

  • Experience in thermal therapies
  • Experience with Radiotherapy procedures
  • Experience writing scientific papers 

We seek a highly motivated scientist who enjoys an multicultural environment and an interdisciplinary project, able to work independently but also as part of a team. As part of the project, the candidate should be willing to work part-time abroad.

Our offer

This 3-year PhD candidate position is funded by the Marie Skłodowska-Curie actions of the European Union's Horizon 2020 research and innovation program under grant agreement No 955625.  The successful applicant will be appointed as fulltime PhD candidate for 3 years with Erasmus MC Cancer Institute. The PhD will be awarded by the Erasmus University Rotterdam (The Netherlands). The Marie Skłodowska-Curie (MSCA) program offers a highly competitive and attractive salary and working conditions. The successful candidates will receive a salary in accordance with the MSCA regulations for early stage researchers. Exact salary will be confirmed upon appointment [Living Allowance = €37.320/year (correction factor to be applied per country) + Monthly mobility allowance = €600. An additional monthly allowance of €500 is applicable depending on family situation. In addition to their individual scientific projects, all fellows will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences.

Your application

See recruitment procedure. You can apply using the online application form. For more information about the position you can contact Prof. G.C. van Rhoon (This email address is being protected from spambots. You need JavaScript enabled to view it.)