(under construction)

Below you can find the researchers involved in Hyperboost, organized per institute;

B1. Academic Medical Center Amsterdam, Universiteit van Amsterdam,The Netherlands (AMC)

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PI's
hans crezee foto

Hans Crezee 

Principal Investigator for hyperthermia research. His research interests focus on the development of hyperthermia techniques to achieve well controlled tumour heating without overheating normal tissue, and using these in clinical studies to establish the clinical benefit of hyperthermia for different tumour sites. Also working in preclinical research into the synergistic actions of hyperthermia and radiotherapy and chemotherapy to arrive at optimal treatment schedules. Long_Bio

Keywords

hyperthermia, phased array systems, radiosensitization

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PetraKok 

 Petra Kok

Senior researcher at the Amsterdam UMC, dept. Radiation oncology. Her research line focuses on several aspects of hyperthermia treatment planning; e.g. clinical planning using on-line adaptive strategies, advanced thermal modelling, MR imaging to reconstruct patient-specific tissue properties, and biological modelling to quantify hyperthermic sensitization. Long_Bio

Keywords

Hyperthermia treatment planning, biological modelling, treatment optimization.

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Przemek 

 Przemek Krawczyk

After obtaining his PhD Cum Laude in 2009, at the AMC, focusing on the interactions between DNA repair and hyperthermia in the context of cancer, he spent 2 years in the lab of Dr. Maria Jasin at the Memorial Sloan Kettering Cancer Center in NY, where he studied the repair of (CRISPR-induced) DNA breaks in vitro and in vivo. Then he established his research group at the Amsterdam UMC, where he currently focuses on (1) the preclinical and translational research related to hyperthermia-based therapies and (2) advanced visualization and analysis of early cellular responses to DNA double-strand breaks induced by x-rays and accelerated particles.

Keywords

Microscopy, DNA repair, Hyperthermia

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Co-PI
lukas stalpers 23 sep 2020

 Lukas Stalpers

studied medicine in Nijmegen, NL where he received his MD (1985), PhD (1991), and training in radiation oncology (1995). He was a junior researcher at Sunnybrook Health Siences Center, University of Toronto (1993), and did a fellowship in neuro-oncology at UCSF San Francisco (1994-1995). Since 1995, he is staff member in radiation oncology at the Amsterdam UMC, location AMC, became chair of the radiation residents training program, and full professor of translational radiotherapy (2015). His focus is on translational research in pelvic tumours, particularly in gynaecological cancer. Together with a team of physicists, radiobiologists and clinicians, he works on methods to improve radiation precision, tumour control i.e. by combined modality treatment of radiation with chemotherapy, hyperthermia and targeted drugs, and to reduce radiation toxicity. Long_Bio

Mentors
 Klaas Franken
 Arlene Oei  

 Arlene Leonie Oei

Arlene Leonie Oei is a group leader of the radiobiology and hyperthermia research at the department of Radiation Oncology, at the Amsterdam UMC. Her research focusses on improving current anti-cancer treatment strategies, by investigating the mechanisms of action of hyperthermia, radiotherapy, PARP1-inhibitors and immune modulators in 2D, 3D in vitro cultures and in in vivo models. Long_Bio

Keywords

Hyperthermia, Radiotherapy, Immunotherapy

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 Arjan Bel  

Arjan Bel

Arjan Bel is head of the radiotherapy physics group at the Amsterdam UMC. His full career he has been working in radiotherapy in academic hospitals as well as a company. His main interests are image guided adaptive radiotherapy and its combination with hyperthermia. He is (co-) author of 150 peer-reviewed papers (check here).

Long_Bio

Keywords

image guided adaptive radiotherapy, hyperthermia, brachytherapy

 Ben Slotman 8  

 Ben Slotman

Since 1998, Ben Slotman has served as Professor and Head of the Department of Radiation Oncology at Vrije Universiteit medical center (VUmc) in Amsterdam, The Netherlands. Since 2019, he is also the head of the department of Radiation Oncology at the Academic Medical Center (AMC) in Amsterdam. His expertise lies mainly in the field of radiotherapy for lung and brain malignancies and the early clinical implementation of new technologies. His research activities are further concentrated on intra- and extracranial stereotactic radiotherapy and the introduction of various new technologies in radiotherapy, most recently stereotactic MRI-guided adaptive radiotherapy. Professor Slotman is the (co-)author of over 400 international peer reviewed publications. Long_Bio

Keywords

(adaptive) Radiotherapy, new technologies

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B2.  Aarhus University, Denmark (AU)

 Aarhus University

PI
 Michael Horsman  

Michael Horsman 

Michael R. Horsman is Professor of Experimental Radiotherapy at Aarhus University in the Department of Experimental Clinical Oncology (ECO), Aarhus University Hospital, Denmark. He obtained a BSc with Honors in Human Biology from Oxford Polytechnic in 1977, a PhD in Radiation Biology from the University of London in 1981, and a Doctor of Medical Science from Aarhus University in 1996. He has published extensively on hyperthermia related topics, especially concerning the role of the tumor microenvironment and vasculature. Long_Bio

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Mentors
 Picture PernilleBE2  

 Pernille Byrialsen Elming

recently finished her PhD, Aarhus University, Denmark, on “Tumour hypoxia and the potential of using exercise and hyperthermia for its elimination” andhas now started her specialist training in Clinical Oncology. Long_Bio

     Jens Overgaard

 

 B3. University of Zurich, Switzerland (KSA)

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PI
Oliver Riesterer   

Prof. Dr. Oliver Riesterer

is the designated head of the Center for Radiation Oncology at Cantonal Hospitals Aarau and Baden. He is also a professor and research associate of the University of Zurich. His major research interests are clinical studies with translational research questions including novel treatment techniques, functional imaging, quantitative image analysis (radiomics), serum and tissue biomarkers and biological modification of radiotherapy by means of hyperthermia. Long_Bio

 Mentors
     Dietmar Marder
 Bodis Stephan 05  

Prof.Dr. Stephan Bodis

has been the Director of the Institute of Radiation Oncology of Kantonsspital Aarau since 2003. In September 2012, he was appointed Full Professor of the Medical Faculty of the University of Zurich and became an Associate Physician in the Department of Radiation Oncology of the University Hospital Zurich.

His work concerns clinical aspects of molecular radiobiology, the application of photon and proton radiotherapy and the combination of hyperthermia with radiotherapy in the treatment of various cancers. The Institute of Radiation Oncology of Kantonsspital Aarau is the only institute in German speaking Switzerland that offers hyperthermia in combination with radiotherapy. Long_Bio

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 B4. Universitäts-klinikum Erlangen, Germany (UKER)

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PI's
Udo Gaipl   

Prof. Dr. rer. nat. habil. Udo S. Gaipl

obtained his Dr. rer. nat. with ward in 2003 and following a 2-year postoc  at the Hospitale San Raffaele in Milano at the tumor immunology unit, he returned to Erlangen as group leader and continued his work on stressed cells as a tool for immune intervention. Since 2007, he heads the Radiation Immunobiology at the Department of Radiation Oncoloyg of the UKER.

Keywords:

radiation-induced immune modulation, hyperthermia, immunophenotyping, clinical trials

Long_Bio

 Oliver Ott  

Prof. Dr.Oliver Ott 

currently works as a consultant for radiation oncology and radiotherapy at the Universitätsklinikum Erlangen, Germany. At the Department for Radiation Oncology, he is leading the subdepartments for medical radiotherapy imaging and treatment planning, for irradiation of benign conditions, and the hyperthermia department including MR-guided partial-body-hyperthermia, regional and local as well as interstitial hyperthermia. Main research interests comprise the development of accelerated partial breast irradiation for early breast cancer (APBI), multimodality treatments including combined radiation, systemic treatments and hyperthermia especially for anal, rectal and bladder cancer and optimized radiotherapy protocols for benign inflammatory-degenerative and hyperproliferative conditions. Long_Bio

Co-PI
 Frey  

PD Dr.-Ing. Dr. habil. med. Benjamin Frey M.Sc.

obtained his Dr.-Ing. with award in 2007 at Technische Universität München. Following a postdoc  and the postdoctoral lecture qualification at the Department of Radiation Oncology, Universitätsklinikum Erlangen he became the deputy head of the Translational Radiation Biology at Universitätsklinikum Erlangen. PD DR. Frey is a specialist in translational and experimental medicine. The focus of his research is the effects of radiation on the immune system. His special focus is on clinical trials and preclinical models, mimicking the real clinical situation.

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Mentor
Prof Fietkau   

Prof. Dr. med. Rainer Fietkau

head of Department of Radiation Oncology at UKER. Principal investigator of 24 clinical studies.Major scientific interests are chemoradiation therapy, combination of radiotherapy with immunotherapy, organ preservation for patients with head & neck tumors, brain tumors, pancreatic cancer, lung cancer, and application of hyperthermia as a radiosensitizer and immune modulator. 

Long_Bio

 

 

B5. Zurich University of Applied Sciences, Switzerland (ZHAW)

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PI
 Portrait Scheidegger  
Prof. Stephan Scheidegger 
works at the Zurich University of Applied Sciences. The field of research includes medical biophysics and systems sciences in medicine. Special focus is set on model-based data analysis and modelling of anticancer treatment using heat and radiation.​ Long_Bio
Key words:
Medical Biophysics, Radiation Biophysics, Systems Medicine
Mentor
 Rudolf M. Füchslin  

Rudolf M. Füchslin

studied theoretical physics at ETH in Zürich and got his PhD from the University of Zurich in the newly established group for computer assisted physics. he acted as a consultant for the Institute for Forensic Medicine fostering interest in biological and medical problems. After various post doc positions on the interface between theoretical biology and engineering, he got a position as professor of applied complex systems science at the Zurich University of Applied Sciences. Co – director of the European Centre for Living Technology in Venice, Italy and president of the Naturama foundation. Long_Bio

Keywords:

Complex systems sciences, evolutionary methods,mathematical modeling

 

 

 B6. Dr. Sennewald Medizintechnik GmbH, Munich, Germany (SMT)

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Co-PI
 Martin Wadepohl  

Martin Wadepohl 

Studied Mechatronics and Medical Engineering at Technical University Ulm, Germany and is now technical director Hyperthermia at University Hospital Grosshadern, Munich, Germany. Martin is a consultant for hospital planning (medical equipment and organization) and product and sales manager Hyperthermia. Long_Bio

Keywords

Medical Engineering, Project and Product Management, Quality Management (ISO 13485) and Regulatory affairs

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Mentor
     Gerhard Sennewald

 

 

 

 

 

 B7. Medlogix Rome, Italy (ALBA)

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Co-PI
Silvia Ciampa   

Sylvia Ciampa 

is involved in the oncological hyperthermia field since 2011, in R&D, regulatory affairs as well as technical sales field. She received the MSc in Bio-engineering in 2012 from the University of Rome Tor Vergata. After a research project carried out at the Amsterdam University Medical Center, she started working at MED-LOGIX srl on the project design and development of the new deep oncological hyperthermia system ALBA 4D. She currently is coordinating MED-LOGIX’s R&D projects and as technical sales engineer to train, support and coordinate the MED-LOGIX international dealers’ network.

Expertise: hyperthermia technologies, R&D, marketing

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 Pierfrancesco Pavoni  

Pierfrancesco Pavoni 

An Italian Olympian inventor and visioner behind the advanced open platform for Hyperthermia in health care named ALBA Precision Hyperthermia.  

An ex world-class sprinter from the 90’s, he experimented the first generation of Oncology Hyperthermia devices as a patient to cure his frequent muscle-tendon lesions. Since then he has been leading different teams of engineers collaborating with Top International Scientific Institutions committed to developing, producing, and selling radiative Hyperthermia devices worldwide. Author of different national and international patents in HT technology, he has more than 30 years of experience in high-tech innovative medical device businesses, having also planned and managed the development, launch and sales of ultrasound imaging devices and extracorporeal electro-hydraulic shock wave technology. Long_Bio

Mentor
 Eugenio Pagliaroli  

Eugenio Pagliaroli

After receiving an MSc in Bio-engineering in 2012 from the University of Rome Tor Vergata he started working at MED-LOGIX srl where he is now the production and service manager. He worked from the beginning on the R&D project of the new deep hyperthermia system ALBA 4D and personally followed all the stages of design, development, testing and certification of the device. He is directly involved in all R&D projects of the company, as part of the team taking care of the design, development and testing of the products.

 

 

B8. Charité – Universitäts-medizin Berlin, Germany (CUB)

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PI
Wust   

Prof. Peter Wust

worked at the University Clinic of Berlin (Charité) since 1984, since 1994 as Consultant for Radiation Oncology (Senior Physician). Since 2006 he is Head of the Outpatient Department of Radiotherapy at the Charité (Ambulantes Gesundheitszentrum, Campus Virchow Klinikum) and is responsible for radiotherapy of ambulatory patients, in special cases in combination with hyperthermia. Long_Bio.

Further information: publications and research profile

Keywords

High frequency-based cell concepts, electrophysiological experiments, high frequency clinical expertise, clinical trials

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Co-PI
   

Dr. Jacek Nadobny

Medical Physicist and Biomedical Engineer

Research interest/key words:

High frequency-based planning and optimization of high frequency applications, development of algorithms to calculate high frequency electromagnetic fields, time independent temperature distributions and/or high frequency effects in cells. Applicator design

Mentor
 Pirus Ghadjar  

 Pirus Ghadjar

Principal investigator of the Interdisciplinary high frequency research group at the Charite. Long_Bio

Reseach focus/key words:

High frequency-based cell concepts, biological, genomic/proteomic-experiments, electrophysiological experiments, high frequency clinical expertise, clinical trials

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 B9. Chalmers University of technology Göteborg, Sweden (CUT)

 Chalmers

 

PI
Hana Trefna 2   

Hana Dobsicek Trefna

is associate professor in the Biomedical electromagnetics research group and an expert in systems and focusing algorithms for microwave hyperthermia treatment of deep seated tumors. Her work aims at clinical introduction of hyperthermia in Sweden, developing an UWB hyperthermia system for treatment of head and neck tumors and exploring the possibility of hyperthermia treatment of brain tumors in children.

Keywords

UWB hyperthermia, Quality assurance, Microwave diagnostics

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Mentor
 Mikael Persson  

Mikael Persson

 is Head of Division for Signal processing and Biomedical engineering, with emphasis on medical applications of electromagnetic fields. He is also one of the initiators of MedTech West - a network and a collaborative platform for research, education, development and evaluation of new biomedical concepts and technologies. Founder and majority shareholder of Medfield Diagnostics AB.

Keywords

Biomedical engineering, Microwave diagnostics, Stroke

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B10.  Erasmus Medical Center Rotterdam, The Netherlands (EMC)

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PI
    Gerard C Van Rhoon 
Mentor
 Franckena Martine  

 Martine Franckena

Member of staff and researcher at the Department of Radiation Oncology, Erasmus MC

Long_Bio

Maarten Paulides  

Maarten Paulides

Director of the Center for Care and Cure Technology Eindhoven (C3Te) of the Electrical Engineering department at Eindhoven University of Technology (TU/e). Associate Professor both in the Electromagnetics group of TU/e and at the Department of Radiation Oncology at Erasmus MC Cancer Institute in Rotterdam. He has the ambition to improve care & cure of patients using electromagnetic technology. He specifically focuses on developing novel diagnostic (MRI) and therapy (neurostimulation, MR guided thermal therapy) approaches, as well as electromagnetic safety. Long_Bio

 Research lab, Personal page

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 B11. Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (MDC)

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PI
 Niendorf Thoralf 9371  

Prof. Dr. rer.nat. Thoralf Niendorf

head, Berlin Ultrahigh Field FacilityMax Delbrück Center for Molecular Medicine in the Helmholtz Association. Long_Bio

Keywords

Biomedical Engineering, Magnetic Resonance, Thermal Magnetic Resonance 

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